So far most of our knowledge are still obtained in vitro instead of in vivo. For C(t) at SOA we try to simulate using established popPK or PBPK models. We typically have in vitro concentrations (IC50) that inhibit viral replication in a test host cell system. Vero cell cultures are often used. The basic idea is to check to see if we can achieve concentrations in patients that approach that IC50.
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