Clinical & Quantitative Pharmacology

What is pharmacokinetics?

The word pharmacokinetics is from two greek words: pharmakon: drug kineticos: to do with motion Pharmacokinetics is a study of the movement of drug in the body. A drug is no different from food. After you swallow a drug, it moves to your stomach where the body begins to absorb the drug. The body then […]

What is clinical pharmacology?

Pharmacology is the science of drugs and how drugs affect your body and how the body responds to the drug.  Every drug that we take changes the chemistry in our body. Clinical pharmacology is a branch within pharmacology that focuses on the application of pharmacological principles and methods in the real world. Resources: British Pharmacological […]

What is quantitative pharmacology?

Quantitative pharmacology or quantitative systems pharmacology (QSP) is a relatively new discipline with enormous potential to improve pharma R&D productivity. Most major pharma organizations are investing in it. QSP may also be able to leverage the enormous amounts of information we now have access to, including genomics and proteomics data. QSP combines computational modeling and […]

Why are clinical and quantitative pharmacology important for COVID-19?

Given the novelty of COVID-19 and lack of any proven therapies, clinical and quantitative pharmacology and translational medicine principles, such as characterization of exposure-response, are pivotal for fighting COVID-19 effectively and efficiently.  Clinical pharmacology is foundational to the “science” of dosing. Critical questions to ask when triaging compounds: -What is our target confidence,  is it […]